Artificial intelligence (AI) is a branch of engineering that has traditionally ignored brains, but recent advances in biologically-inspired deep learning have dramatically changed AI and made it possible to solve difficult problems in vision, planning and natural language. If you talk to Alexa or use Google Translate, you have experienced deep learning in action. This new technology opens a Pandora's box of problems that we must confront regarding privacy, bias and jobs. Terry Sejnowski, PhD, explains how his research strives to understand the computational resources of brains and to build linking principles from brain to behavior using computational models.